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Irmgard Tegeder Selected Research

GTP Cyclohydrolase (GTP Cyclohydrolase I)

6/2015Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.
4/2013Author's reply to Kapoor S. GTP cyclohydrolase and cancer pain.
2/2013Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages.
12/2012Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine.
8/2009Current evidence for a modulation of low back pain by human genetic variants.
11/2008Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.
9/2008Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.
6/2007Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.
11/2006GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.

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Irmgard Tegeder Research Topics

Disease

41Pain (Aches)
10/2020 - 01/2002
24Inflammation (Inflammations)
01/2021 - 03/2003
20Neuralgia (Stump Neuralgia)
08/2021 - 02/2004
18Hyperalgesia
11/2014 - 10/2002
11Neoplasms (Cancer)
01/2022 - 04/2003
10Hypersensitivity (Allergy)
08/2021 - 12/2009
7Chronic Pain
08/2021 - 06/2005
7Peripheral Nerve Injuries
11/2017 - 02/2008
6Multiple Sclerosis
01/2021 - 11/2014
5Starvation
08/2021 - 01/2017
4Traumatic Brain Injuries (Traumatic Brain Injury)
04/2022 - 01/2017
4Mental Disorders (Mental Disorder)
09/2021 - 01/2016
4Neuroblastoma
03/2021 - 01/2017
4Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
10/2020 - 11/2014
4Nausea
02/2016 - 01/2002
3Neoplasm Metastasis (Metastasis)
01/2022 - 01/2014
3Brain Injuries (Brain Injury)
01/2021 - 01/2017
3Gliosis
10/2018 - 01/2017
3Frontotemporal Dementia (Semantic Dementia)
10/2018 - 04/2012
3Cancer Pain
02/2016 - 12/2012
3Infections
04/2015 - 05/2002
2Parkinson Disease (Parkinson's Disease)
08/2021 - 10/2020
2Neurodegenerative Diseases (Neurodegenerative Disease)
08/2021 - 07/2004
2Alzheimer Disease (Alzheimer's Disease)
08/2021 - 11/2014
2Encephalomyelitis (Myeloencephalitis)
01/2021 - 10/2020
2Encephalitis (Encephalitis, Rasmussen)
01/2021 - 01/2017
2Hypoxia (Hypoxemia)
12/2018 - 06/2014
2Colitis
01/2017 - 08/2016
2Neuroinflammatory Diseases
01/2017 - 04/2015
2Phenylketonurias (Phenylketonuria)
08/2016 - 09/2008
2Melanoma (Melanoma, Malignant)
01/2014 - 12/2012
2Colonic Neoplasms (Colon Cancer)
02/2013 - 07/2003
2Dopa-responsive Dystonia
09/2008 - 06/2007
2Edema (Dropsy)
02/2004 - 03/2003
2Skin Diseases (Skin Disease)
11/2002 - 03/2002
1Hyperphagia (Overeating)
01/2022
1Overweight
11/2021
1Immune System Diseases (Immune Disorders)
11/2021
1Glioma (Gliomas)
11/2021
1Glioblastoma (Glioblastoma Multiforme)
11/2021

Drug/Important Bio-Agent (IBA)

16Proteins (Proteins, Gene)FDA Link
08/2021 - 07/2004
13ProgranulinsIBA
11/2021 - 04/2012
10EndocannabinoidsIBA
09/2021 - 07/2007
9Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2018 - 11/2006
9GTP Cyclohydrolase (GTP Cyclohydrolase I)IBA
06/2015 - 11/2006
8LipidsIBA
01/2022 - 01/2016
7Pharmaceutical PreparationsIBA
01/2021 - 01/2002
7ZymosanIBA
09/2011 - 03/2003
6sapropterin (tetrahydrobiopterin)FDA Link
01/2021 - 11/2006
6Analgesics (Analgesic Drugs)IBA
04/2015 - 05/2003
6Formaldehyde (Formol)FDA Link
06/2014 - 03/2003
6Opioid Analgesics (Opioids)IBA
12/2012 - 01/2002
5Flurbiprofen (Froben)FDA LinkGeneric
12/2016 - 07/2003
5Glutamic Acid (Glutamate)FDA Link
01/2016 - 05/2005
4Sirolimus (Rapamycin)FDA Link
11/2021 - 12/2018
4Reactive Oxygen Species (Oxygen Radicals)IBA
11/2021 - 08/2016
4anandamide (arachidonylethanolamide)IBA
10/2020 - 08/2013
4ProteomeIBA
01/2019 - 01/2017
3Phosphotransferases (Kinase)IBA
01/2022 - 05/2012
3CeramidesIBA
09/2021 - 08/2016
3Transcription Factors (Transcription Factor)IBA
08/2021 - 06/2014
3Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
01/2017 - 06/2011
3CytokinesIBA
01/2017 - 05/2012
3EnzymesIBA
12/2015 - 11/2006
3Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
11/2014 - 03/2003
3Cyclic GMP-Dependent Protein Kinase Type IIBA
08/2008 - 03/2004
2dihydroceramide desaturaseIBA
11/2021 - 01/2017
2SphingolipidsIBA
09/2021 - 01/2019
2SynucleinsIBA
08/2021 - 01/2019
2Small Interfering RNA (siRNA)IBA
03/2021 - 04/2012
2Phospholipids (Phosphatides)FDA LinkGeneric
11/2020 - 01/2018
2Monoclonal AntibodiesIBA
10/2020 - 09/2017
2Hypoxia-Inducible Factor 1IBA
12/2018 - 06/2014
2Glycoproteins (Glycoprotein)IBA
01/2018 - 01/2017
2LigandsIBA
01/2018 - 02/2008
2Interleukin-6 (Interleukin 6)IBA
01/2017 - 08/2009
2ProstaglandinsIBA
12/2016 - 08/2009
2glyceryl 2-arachidonate (2-arachidonoylglycerol)IBA
02/2016 - 01/2014
2fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA
04/2015 - 08/2009
2Capsaicin (Zostrix)FDA Link
06/2014 - 11/2008
2Transient Receptor Potential ChannelsIBA
06/2014 - 08/2009
2CalciumIBA
06/2014 - 04/2011
2ChemokinesIBA
02/2013 - 05/2012
2Morphine (MS Contin)FDA LinkGeneric
12/2012 - 04/2003
2Ion Channels (Ion Channel)IBA
01/2012 - 05/2006
2GTP-Binding Proteins (G-Protein)IBA
01/2012 - 04/2003
2Protein Kinases (Protein Kinase)IBA
09/2011 - 03/2003
2Peptide Hydrolases (Proteases)FDA Link
04/2011 - 07/2004
2CannabinoidsIBA
05/2010 - 07/2007
2Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
08/2009 - 01/2002
2Synapsins (Synapsin I)IBA
10/2008 - 05/2005
1Triglycerides (Triacylglycerol)IBA
04/2022
1phosphatidylethanolamineIBA
04/2022
1Dietary Fats (Dietary Fat)IBA
11/2021
1Scavenger Receptors (Scavenger Receptor)IBA
11/2021
1NADPH Oxidase 2IBA
11/2021
1Valosin Containing ProteinIBA
11/2021
1Bovine Serum AlbuminIBA
11/2021
1Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
11/2021

Therapy/Procedure

5Therapeutics
09/2017 - 11/2002